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. Author manuscript; available in PMC: 2020 Jan 28.
Published in final edited form as: J Control Release. 2018 Nov 27;294:53–76. doi: 10.1016/j.jconrel.2018.11.024

Figure 6.

Figure 6.

Examples of common methods to make cellulose nanocrystal (CNC)-based cargo delivery systems. (a) Direct chemical modifications of CNC surface to conjugate Cltx via the Fisher esterification of the hydroxyl groups of CNC and the carboxylic acid groups of a drug in a Brønsted acid ionic liquid [90], reproduced from [90] with permission from the Centre National de la Recherche Scientifique (CNRS) and The Royal Society of Chemistry. (b) Solvent casting of CNC-alginate nanocomposites crosslinked using calcium ions. Carbohydr. Polym., 1:186–195, Copyright (2018), with permission from Elsevier [126]. This platform may be used to encapsulate active molecule of choice. (c) Self-assembly through the electrostatic adsorption of sulfuric acid-hydrolyzed CNC (bacterial) with amine-bearing polymers [127]. Reprinted with permission from [127]. Copyright (2018) American Chemical Society.