Table 2.
Odds ratio and 95% confidence interval of thiazolidinediones cancer by multivariable logistical regression model.
| Crude | Adjusted† | |||
|---|---|---|---|---|
| Variable | OR | (95% CI) | OR | (95% CI) |
| Sex (male vs. female) | 1.03 | (0.99, 1.07) | ||
| Age (per one year) | 1.00 | (0.99, 1.003) | ||
| Thiazolidinediones use (never used as a reference) | 0.99 | (0.94, 1 .04) | 0.94 | (0.89, 0.99) |
| Other anti-diabetic drugs use (never used as a reference) | 1.33 | (1.26, 1.40) | 1.35 | (1.27, 1.42) |
| Comorbidities before index date (yes vs. no) | ||||
| Alcohol-related disease | 1.16 | (1.06, 1.26) | 1.15 | (1.06, 1.26) |
| Cardiovascular disease | 0.97 | (0.93, 1.01) | ||
| Chronic kidney disease | 1.00 | (0.95, 1.06) | ||
| Chronic liver diseases | 1.03 | (0.98, 1.07) | ||
| Chronic obstructive pulmonary disease | 1.003 | (0.96, 1.05) | ||
| Colorectal adenoma | 1.11 | (0.96, 1.29) | ||
| Hyperlipidemia | 0.99 | (0.96, 1.03) | ||
| Hypertension | 0.97 | (0.93, 1.02) | ||
| Inflammatory bowel disease | 1.14 | (0.98, 1.33) | ||
†
Variables which were statistically associated with colorectal cancer in a univariable model were further included in a multivariable model. Only other anti-diabetic drugs and alcohol-related disease were included for adjustment.