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Hyperglycemia-induced PECAM-1 loss in RRMECs. (A) PECAM-1 mean band densities were significantly reduced in RRMECs grown under high glucose conditions. (B) PECAM-1 in RRMECs incubated with equal osmolarity to HG media. (C) Truncated PECAM-1 was increased in RRMECs under hyperglycemic conditions. Western blotting data is a comparison of the relative PECAM-1/β-actin band densities. *P < 0.05 versus NG, #P < 0.05 versus NaCl, dextran, and mannitol; N = 3 per group.
