Fig. 1. (A) Biosynthetic gene cluster for the McC toxin from E. coli. (B) MccB-catalyzed production of the peptide-adenylate resulting in installation of an N–P linkage. (C) Chemical structures of aspartyl adenylate generated by aspartyl-tRNA. Synthetase (5) and the processed McC toxin (6). Mature McC toxin (6) has a tailoring aminopropyl modification that increases it affinity for the target.
