Figure 1.

Frequency of pacemaker activity was greater, and amplitude reduced, in Lep^ob antrums. Representative intracellular microelectrode recordings from the antrums of wild-type (A) and Lep^ob (B) mice. Note the depolarized membrane potential, increased frequency, and decreased amplitude of slow waves in Lep^ob antrums. Time scale in B applies to both A and B. C–F: Summarized data demonstrating differences in slow wave parameters between wild-type (white bars) and Lep^ob antrums (black bars). Increase in slow wave frequency (C), reduction in slow wave amplitude (D), reduction in ISWP (E), and reduction in half-maximal duration of slow waves (F) (unpaired Student t test). Representative isometric force recordings from the antrums of wild-type (G) and Lep^ob (H) mice. Summarized data showing increased frequency (I) and reduced amplitude (J) of contractions in Lep^ob, as compared with wild-type (unpaired Student t test). *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001; ****P ≤ 0.0001.