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. 2019 Feb 14;12:239–255. doi: 10.2147/DMSO.S191759

Table 7.

Interactions of the seven TCF7L2 SNPs with dietary patterns under additive and a dominant model of analysis

SNPs Groups Genotypes N Dietary patterns Additive model Dominant model
Fruit Meats Dairy product Vegetables Grains Passociation, GG vs GC Passociation, GG vs CC Passociation, GC vs CC Overall Pinteraction Passociation, GG + GC vs CC
rs11196205 T2DM CC 25 3 4 7 2 9 0.877 0.614 0.683 0.222 0.629
GC 115 15 25 20 22 33
GG 156 22 31 37 18 48
Control CC 36 6 6 4 9 11 0.848 0.081 0.135 0.090
GC 190 43 28 41 44 34
GG 218 53 22 49 68 26
Passociation, TT vs GT Passociation, TT vs GG Passociation, TG vsGG Overall Pinteraction Passociation, TT+ GT vs GG
rs12255372 T2DM GG 207 29 42 46 25 65 0.769 0.944 0.781 0.126 0.810
GT 79 11 15 13 17 23
TT 9 0 2 5 0 2
Control GG 305 70 36 69 91 39 0.785 0.607 0.495 0.440
GT 126 30 16 24 28 28
TT 13 2 4 1 2 4
Passociation, AA vs GA Passociation, AA vs GG Passociation, AG vs GG Overall Pinteraction Passociation, AA+ GA vs GG
rs12573128 T2DM GG 58 7 6 17 11 17 0.301 0.207 0.647 0.237 0.360
GA 128 15 28 27 16 42
AA 110 18 26 20 15 31
Control GG 61 14 10 14 17 6 0.880 0.347 0.353 0.319
GA 228 50 30 46 68 34
AA 157 38 16 35 37 31
Passociation, TT vs AT Passociation, TT vs AA Passociation, TA vsAA Overall Pinteraction Passociation, TT+ AT vs AA
rs4506565 T2DM AA 196 27 43 43 23 60 0.930 0.650 0.549 0.033 0.490
AT 85 12 14 16 18 25
TT 15 1 3 5 1 5
Control AA 287 66 31 63 90 37 0.548 0.482 0.994 0.869
AT 147 34 22 31 30 30
TT 12 2 3 1 2 4
Passociation, AA vs GA Passociation, AA vs GG Passociation, AG vs GG Overall Pinteraction Passociation, AA+ GA vs GG
rs7895340 T2DM GG 159 22 32 37 19 49 0.869 0.794 0.882 0.267 0.830
GA 113 15 24 20 21 33
AA 24 3 4 7 2 8
Control GG 221 53 23 49 70 26 0.102 0.060 0.911 0.507
GA 187 43 27 41 42 34
AA 35 6 5 4 9 11
Passociation, TT vs CT Passociation, TT vs CC Passociation, TC vs CC Overall Pinteraction Passociation, TT+ CT vs CC
rs7901695 T2DM CC 14 1 3 4 1 5 0.481 0.607 0.886 0.072 0.680
CT 82 12 13 15 17 25
TT 200 27 44 45 24 60
Control CC 12 2 3 1 2 4 0.933 0.490 0.534 0.498
CT 145 33 22 31 31 28
TT 289 67 31 63 89 39
Passociation, TT vs CT Passociation, TT vs CC Passociation, TC vs CC Overall Pinteraction Passociation, TT+ CT vs CC
rs7903146 T2DM CC 197 27 43 43 23 61 0.961 0.700 0.649 0.031 0.591
CT 83 12 14 15 18 24
TT 16 1 3 6 1 5
Control CC 287 66 31 63 90 37 0.548 0.481 0.994 0.869
CT 147 34 22 31 30 30
TT 12 2 3 1 2 4

Abbreviations: SNP, single-nucleotide polymorphism; T2DM, type 2 dietary mellitus.