Fig. 7. (a) NOE-restrained Molecular Dynamics simulations of cLAGAY (25 in cyan) and oxetane modified cLAGOxAY (13 in green). For each, a total of 10 representative structures are overlaid. (b) Peptide backbones of 13 and 25 with side-chains omitted for clarity. For 13, intramolecular H-bond is indicated (yellow dots). (c) Ramachandran plots showing dihedral angles φ against Φ for the amino acid residues within 13 and 25.
