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. Author manuscript; available in PMC: 2019 Feb 22.

Published in final edited form as: Chem Biol Drug Des. 2011 Dec 22;79(2):157–165. doi: 10.1111/j.1747-0285.2011.01270.x

Table 2.

Inhibitory potencies in vitro using wild-type (WT) and mutant integrase enzymes.^a

No.	ST IC₅₀ (μM, WT)	Mutants^b
No.	ST IC₅₀ (μM, WT)	G140S/Q148H	Y143R	N155H
1	0.067	105x	26x	7x
5e	7.1 ± 0.6	12x	2x	4x

^a

Data was obtained as described in Experimental Section.

^b

Fold-loss of potency relative to virus containing WT enzyme.