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The location of GPCR endo-lysosomal sorting signals. Sites of ubiquitination required for lysosomal degradation sorting have been mapped to intracellular loop (ICL) 1 and 3, as well as the C-terminal tail of the GPCRs listed (green). In contrast, YPX3L motifs required for lysosomal sorting have been discovered in ICL-2 of the GPCRs listed (orange).
