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. 2018 Jun 5;11(5):111–114. doi: 10.1002/cld.702

Figure 2.

Figure 2

(A) In normal liver tissue, HSCs are quiescent and reside in the space of Disse, the subendothelial space between hepatocytes and endothelial cells. (B) Liver injury results in HSC activation and in turn multiple inflammatory cells are recruited and migrate across the endothelial layer. Together these cells secrete profibrotic cytokines and result in collagen deposition and modification. As seen, the HSC has changed morphology and is now activated and surrounded by collagen fibrils.