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. 2018 Dec 4;9(2):345–357. doi: 10.1534/g3.118.200705

Figure 2.

Figure 2

HIPP1 is the fly homolog of human CDYL. Shown is a diagram of the HIPP1 protein, highlighting the C-terminal crotonase-like domain (amino acids 666 to 926, CLD, red). Below the protein diagram is an alignment of the HIPP1 CLD with crotonase domains from human CDYLb, Enoyl-coA hydratase, and bacterial Crotonase. Shading indicates identical (dark purple) and similar (light purple, PAM250 matrix score >0.5) residues. Red boxes show the location of the three structural amino acid residues (red boxes) that are predicted to form the oxyanion hole in CDYL (Wu et al. 2009).