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. 2018 Dec 21;9(2):491–503. doi: 10.1534/g3.118.200874

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Copyright © 2019 Matera et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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CG14164/Hezron is orthologous to Lsm12, not Gemin6. Top: Schematic of human Lsm12 and Gemin6, with pairwise alignment scores to CG14164 showing %similarity and %identity. Bottom: Amino acid alignment of Lsm12 and Gemin6 (Gem6) protein sequences from a variety of metazoan species, including: Homo sapiens (Hsap), Gallus gallus (Ggal), Danio rerio (Drer), Lygus hesperus (Lhes), and Nasonia vitripennis (Nvit). Two paralogous D. melanogaster proteins CG15735 and CG14164, are shown for comparison. Each of the fruitfly proteins shows a high degree of similarity to Lsm12, as compared to Gemin6. Diagnostic residues shaded in red are highly conserved in Lsm12 orthologs and those shaded in blue are conserved in the Gem6 orthologs. Residues bolded in black are conserved among all of the proteins.