Figure 2.

Fingolimod causes ILC-penia in human peripheral blood. (A) absolute number of total or subsets of ILCs in the peripheral blood of MS patients treated with fingolimod (n = 14) or untreated control MS patients (n = 11) per 10 ml peripheral blood. Total ILCs were gated as CD127⁺CD161⁺CD3⁻Lin⁻ cells, ILC3s as cKit⁺CRTH2⁻CD127⁺ CD161⁺ CD3⁻Lin⁻, ILC2s as CRTH2⁺CD127⁺CD161⁺ CD3⁻Lin⁻, and ILC1s as cKit⁻CRTH2⁻CD127⁺ CD161⁺CD3⁻Lin⁻. (B) percentages of ILCs in “A”. *Indicates p < 0.05.