Table 4.
List of scenario analyses
| Scenario | Purpose |
|---|---|
| 1.5% discount rate | To assess the impact of varying the discount rate applied to costs and outcomes on the results of the model |
| 6% discount rate | |
| 10-year time horizon | To assess the impact of varying the time horizon on the results of the model |
| 20-year time horizon | |
| 30-year time horizon | |
| Lognormal distribution for PFS | To assess the impact of varying the parametric distribution for PFS on the model results |
| Log-logistic curve for PFS | |
| Spline normal k = 1 distribution for PFS | |
| Spline odds k = 3 distribution for PFS | |
| Log-logistic distribution for RS OS anchor | To assess the impact of varying the parametric distribution for OS on the model results |
| Lognormal distribution for TTD | To assess the impact of varying the parametric distribution for TTD on the model results |
| No cap on TTD and PFS | To assess the impact of varying the time cap applied to PFS and TTD within the model |
| 15-year cap on TTD and PFS | |
| PFS:OS = 1:3 | To assess the impact of varying the mean PFS and OS difference relationship on the model results |
| PFS:OS = 1:1 | |
| PFS:OS = 1:1.5 | |
| PFS:OS = 1:2.5 | |
| AE disutilities not included | To assess the impact of removing AE disutilities from the model on the results |
AE adverse event, k knotts, OS overall survival, PFS progression-free survival, RS routine surveillance, TTD time to treatment discontinuation