Niraparib reduced costs and increased quality-adjusted life-years (QALYs) compared to olaparib and rucaparib, dominating both treatments. Therefore, niraparib was cost-effective compared to olaparib and rucaparib in both the gBRCAmut and non-gBRCAmut populations from a US payer perspective.

Niraparib increased costs and QALYs compared to routine surveillance. The resulting incremental cost-effectiveness ratio led to niraparib being considered cost-effective compared to routine surveillance in both the gBRCAmut and non-gBRCAmut populations from a US payer perspective.