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. Author manuscript; available in PMC: 2019 Aug 15.
Published in final edited form as: Science. 2019 Jan 31;363(6428):710–714. doi: 10.1126/science.aaw5569

Figure 4. Unexpected factors stabilize the P-complex conformation.

Figure 4

(A to C) FAM32A and NKAP promote binding of Slu7 to the P complex. Prp8EN, Prp8 endonuclease domain. (D and E) Cactin stabilizes the position of the branch helix for exon ligation. Dashed lines indicate possible path of the intron not visible in the density. Py tract, polypyrimidine tract. (F) Novel factors position the branch helix. (G) SDE2 promotes Cactin binding near the branch helix. The loop of Cactin that projects a positive surface onto the branch helix is highlighted in magenta.