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. Author manuscript; available in PMC: 2019 Aug 15.
Published in final edited form as: Science. 2019 Jan 31;363(6428):710–714. doi: 10.1126/science.aaw5569

Figure 5. Model for the action of exon ligation factors in metazoans.

Figure 5

After Prp16 dissociates Cwc25 and Yju2 from C complex, Slu7, PRKRIP1, and FAM32A can bind the remodeled C* conformation. Cactin may bind before, or concomitantly with, docking of the 3´-exon at the catalytic core and associates more strongly upon 3´SS docking. SDE2 is likely present already in the C complex, as it interacts with the NTC, remains bound throughout the catalytic stage and promotes Cactin binding after remodeling by Prp16. FAM32A binds the 5´-exon and likely stabilizes docking of the 3´SS onto the 5´SS and BP adenosine.