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. Author manuscript; available in PMC: 2019 Feb 22.
Published in final edited form as: Microbiol Spectr. 2019 Jan;7(1):10.1128/microbiolspec.PSIB-0004-2018. doi: 10.1128/microbiolspec.PSIB-0004-2018

TABLE 1.

Staphylococcus aureus cell wall-anchored surface proteins 1.

Sortase A anchored protein Name(s) Genbank accession number aa 2 Ligand(s) 3 YSIRK Motif 4 Sorting Motif 5 Reference
Adenosine synthase A AdsA (SasH) ABD22278.1 772 Adenosine and dAdo synthesis No LPKTG (106, 108)
Clumping Factor A ClfA ABD20644.1 933 Fibrinogen (γ chain) Factor I Yes LPDTG (145, 146)
Clumping Factor B ClfB ABD21326.1 899 Fibrinogen (α chain) Cytokeratin 8 & 10 Loricrin Yes LPETG (97102)
Collagen adhesin Cna BAF45800.1 1,183 Collagen C1q No LPKTG (147, 148)
Factor affecting methicillin resistance in Triton X-100 B FmtB (SasB) ATC68490.1 2,478 Unknown Yes LPDTG (149)
Fibronectin binding protein A FnbpA ABD21634.1 1,018 Fibronectin Fibrinogen (γ chain) Elastin Yes LPETG (30)
Fibronectin binding protein B FnbpB ABD22827.1 940 Fibronectin Fibrinogen (α chain) Elastin Yes LPETG (30)
Iron-regulated surface determinant A IsdA (SasE) ABD21627.1 350 Heme transferred from IsdB/H No LPKTG (35)
Iron-regulated surface determinant B IsdB (SasJ) ABD21843.1 645 Hemoglobin Heme Yes LPQTG (3639)
Iron-regulated surface determinant H IsdH (SasI/HarA) ABD20516.1 895 HaptoglobinHemoglobin Heme Yes LPKTG (3640)
Plasmin sensitive surface protein Pls AAD09131.1 1,637 Unknown Yes LPDTG (150, 151)
S. aureus surface -protein C SasC ABD21355.1 2,186 Promotes intercellular adhesion Yes LPNTG (152)
S. aureus surface -protein D SasD ABD21427.1 241 Unknown No LPAAG
S. aureus surface -protein F SasF ABD21199.1 635 Unknown No LPKAG
S. aureus surface -protein G SasG BAU36055.1 1,115 Unknown Yes LPKTG
S. aureus surface -protein K SasK ADC38744.1 211 Unknown No LPKTG
Serine aspartic repeat -protein C SdrC ABD21592.1 947 β-neurexin Homophylic bonds Yes LPETG (153, 154)
Serine aspartic repeat -protein D SdrD ABD20874.1 1,381 Desmoglein 1 Yes LPETG (155)
Serine aspartic repeat -protein E SdrE ABD22410.1 1,154 Factor H Yes LPETG (156)
S. aureus protein A SpA ABD22331.1 508 Immunoglobulin (Fcγ, Fab VH3) Yes LPETG (70, 71, 157, 158)
Serine-rich adhesin for platelets SraP (SasA) ABD21900.1 2,271 Salivary agglutinin (gp340) Possibly LPDTG (34, 159)
Sortase B anchored protein Name(s) Genbank accession number aa1 Ligand(s)2 YSIRK motif3 Sorting motif4 Reference
Iron-regulated surface determinant C IsdC ABD20415.1 227 Heme transferred from IsdA No NPQTN (28)
1

The number of cell wall-anchored surface proteins varies among strains 272 of S. aureus (26). For example, in strain S. aureus subsp. aureus USA300_FPR3757, genes for Cna, SasK, and Pls are missing; the presence of stop codons results in truncated FmtB (SasB), SasC and SasG products.

2

aa, protein length in amino acids.

3

Molecular component(s) recognized and bound by protein, or molecules synthesized in case of AdsA.

4

Consensus motif found in some signal sequences which presumably accounts for secretion of proteins at the cross walls (62).

5

Consensus motif recognized by sortases and present in C-terminal cell wall sorting signal.