TABLE 1.
Sortase A anchored protein | Name(s) | Genbank accession number | aa 2 | Ligand(s) 3 | YSIRK Motif 4 | Sorting Motif 5 | Reference |
Adenosine synthase A | AdsA (SasH) | ABD22278.1 | 772 | Adenosine and dAdo synthesis | No | LPKTG | (106, 108) |
Clumping Factor A | ClfA | ABD20644.1 | 933 | Fibrinogen (γ chain) Factor I | Yes | LPDTG | (145, 146) |
Clumping Factor B | ClfB | ABD21326.1 | 899 | Fibrinogen (α chain) Cytokeratin 8 & 10 Loricrin | Yes | LPETG | (97–102) |
Collagen adhesin | Cna | BAF45800.1 | 1,183 | Collagen C1q | No | LPKTG | (147, 148) |
Factor affecting methicillin resistance in Triton X-100 B | FmtB (SasB) | ATC68490.1 | 2,478 | Unknown | Yes | LPDTG | (149) |
Fibronectin binding protein A | FnbpA | ABD21634.1 | 1,018 | Fibronectin Fibrinogen (γ chain) Elastin | Yes | LPETG | (30) |
Fibronectin binding protein B | FnbpB | ABD22827.1 | 940 | Fibronectin Fibrinogen (α chain) Elastin | Yes | LPETG | (30) |
Iron-regulated surface determinant A | IsdA (SasE) | ABD21627.1 | 350 | Heme transferred from IsdB/H | No | LPKTG | (35) |
Iron-regulated surface determinant B | IsdB (SasJ) | ABD21843.1 | 645 | Hemoglobin Heme | Yes | LPQTG | (36–39) |
Iron-regulated surface determinant H | IsdH (SasI/HarA) | ABD20516.1 | 895 | HaptoglobinHemoglobin Heme | Yes | LPKTG | (36–40) |
Plasmin sensitive surface protein | Pls | AAD09131.1 | 1,637 | Unknown | Yes | LPDTG | (150, 151) |
S. aureus surface -protein C | SasC | ABD21355.1 | 2,186 | Promotes intercellular adhesion | Yes | LPNTG | (152) |
S. aureus surface -protein D | SasD | ABD21427.1 | 241 | Unknown | No | LPAAG | |
S. aureus surface -protein F | SasF | ABD21199.1 | 635 | Unknown | No | LPKAG | |
S. aureus surface -protein G | SasG | BAU36055.1 | 1,115 | Unknown | Yes | LPKTG | |
S. aureus surface -protein K | SasK | ADC38744.1 | 211 | Unknown | No | LPKTG | |
Serine aspartic repeat -protein C | SdrC | ABD21592.1 | 947 | β-neurexin Homophylic bonds | Yes | LPETG | (153, 154) |
Serine aspartic repeat -protein D | SdrD | ABD20874.1 | 1,381 | Desmoglein 1 | Yes | LPETG | (155) |
Serine aspartic repeat -protein E | SdrE | ABD22410.1 | 1,154 | Factor H | Yes | LPETG | (156) |
S. aureus protein A | SpA | ABD22331.1 | 508 | Immunoglobulin (Fcγ, Fab VH3) | Yes | LPETG | (70, 71, 157, 158) |
Serine-rich adhesin for platelets | SraP (SasA) | ABD21900.1 | 2,271 | Salivary agglutinin (gp340) | Possibly | LPDTG | (34, 159) |
Sortase B anchored protein | Name(s) | Genbank accession number | aa1 | Ligand(s)2 | YSIRK motif3 | Sorting motif4 | Reference |
Iron-regulated surface determinant C | IsdC | ABD20415.1 | 227 | Heme transferred from IsdA | No | NPQTN | (28) |
The number of cell wall-anchored surface proteins varies among strains 272 of S. aureus (26). For example, in strain S. aureus subsp. aureus USA300_FPR3757, genes for Cna, SasK, and Pls are missing; the presence of stop codons results in truncated FmtB (SasB), SasC and SasG products.
aa, protein length in amino acids.
Molecular component(s) recognized and bound by protein, or molecules synthesized in case of AdsA.
Consensus motif found in some signal sequences which presumably accounts for secretion of proteins at the cross walls (62).
Consensus motif recognized by sortases and present in C-terminal cell wall sorting signal.