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. Author manuscript; available in PMC: 2019 Feb 22.
Published in final edited form as: J Nucl Med. 2012 Nov 8;53(12):1933–1942. doi: 10.2967/jnumed.112.105056

FIGURE 2.

FIGURE 2.

GLV-1h153 mediates radiotracer retention for at least 24 h after administration. (A) 124I PET image signal was strongest at 1 h after radiotracer injection and gradually declined over 72 h. (B) Time–activity curves were generated from PET images using ROIs manually drawn over tumors. Radiouptake mediated and enhanced by hNIS in GLV-1h153–infected tumors could be serially monitored and measured, with quantitative uptake being strongest at 1 h after radiotracer injection and exponentially declining over 72 h. Maximum radio-uptake ranged from approximately 8–11 %ID/g for intravenous and intratumoral groups at both week 1 and week 2 after virus injection, highlighting tumor-homing ability of GLV-1h153. M1, M2, M3, and M4 = mouse 1, mouse 2, mouse 3, and mouse 4, respectively.