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. Author manuscript; available in PMC: 2019 Feb 22.
Published in final edited form as: J Nucl Med. 2012 Nov 8;53(12):1933–1942. doi: 10.2967/jnumed.112.105056

FIGURE 5.

FIGURE 5.

Autoradiography of tumors injected with GLV-1h153. (A) Tissue radio-gram using 99mTcO4 revealed hot spots of radiouptake in GLV-1h153 tumors correlating with expression of GFP and Hoechst staining, revealing requirement for both presence of GLV-1h153 infection and adequate blood flow to deliver radiotracer. Areas that lacked GFP and thus virus and areas noted on H&E staining to be necrotic and lacking blood flow did not support up-take. No uptake was noted in untreated control tumors despite adequate blood flow. (B) Enlarged merged sections correlated hot spots with GFP and Hoechst dye (shown with arrows).