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. Author manuscript; available in PMC: 2019 Feb 22.
Published in final edited form as: Nat Neurosci. 2018 Aug 27;21(9):1161–1170. doi: 10.1038/s41593-018-0206-1

Figure 1.

Figure 1.

a) QQ-plot of the distribution of the −log 10(p-values) observed for the SNP associations with lifetime cannabis use against those expected under the null hypothesis

Expected −log 10(p-values) under the null hypothesis are indicated by the red line. Genomic inflation is indicated with λ in the plot. There was no evidence for population stratification (LD score regression b0=1.00, SE=0.007).

b) Manhattan plot for the SNP-based GWAS meta-analysis

Results are based on N=184,764 individuals and NSNPs=11,733,371 SNPs. The SNP with the lowest p-value per independent (R2<0.1, window size 250 kb) genome-wide significant locus is annotated (red circle with rs-number). The red line represents the conventional genome-wide significance threshold of p<5e-08. The statistical test comprised linear regression; significance was tested two-sided.