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. Author manuscript; available in PMC: 2019 Feb 22.
Published in final edited form as: Nat Neurosci. 2018 Aug 27;21(9):1161–1170. doi: 10.1038/s41593-018-0206-1

Figure 3.

Figure 3.

a) QQ-plot of the distribution of the −log10(p-values) for the gene-based association with lifetime cannabis use against those expected under the null hypothesis

Expected −log 10(p-values) under the null hypothesis are indicated by the red line. Genomic inflation is indicated with λ. The gene-based test was performed in MAGMA, which uses multiple regression (tested two-sided).

b) Manhattan plot for the gene-based test of association

The red line represents the genome-wide significance threshold of p<2.74e-06, (Bonferroni corrected p-value threshold of p<0.05 adjusted for 18,293 tests; NSNPs=5,710,956 were mapped to at least one gene). The top-gene (with the lowest p-value) per locus is annotated (red circle with gene symbol).