Table 1.

Summary of successful experimental targets for pharmaceutical AAA stabilization.

Targeted cluster	Strategy
Anti-inflammatory	NFκB,⁵⁴ AP-1,⁵⁵ Rho kinase⁵⁶ inhibition IL1,⁵⁷ TNFα,⁵⁸ CCL-1⁵⁹ B-cell⁶⁰; γδT-cell⁶¹ depletion Neutrophil inhibition⁶² Mast cell inhibition⁶³ Complement inhibition^64,65 Oxilipin inhibition^66,67 Immune suppression^68,69
Protease inhibition	MMP inhibition^70,71 Cysteine protease inhibition^72,73 Serine protease inhibition^74,75
Oxidative stress	Antioxidant enzymes^76,77 Secondary antioxidants^78,79
Blood pressure lowering	B-blockers⁸⁰ Ca-Antagonists⁸¹ ACE-inhibitors^82,83 ATR-1 antagonists⁸⁴ iNOS inhibition⁸⁵
Lipid metabolism	Statins^86,87 HDL⁸⁸ RXR and PPARα/γ activation^89,90
Cell Therapy	Mesenchymal stem cells^91,92 Fibroblasts⁹³
Matrix/Morphogens	Interference with TGFβ signalling⁹⁴ Interference with NOTCH⁹⁵/Wnt⁹⁶ signalling Thrombospontin inhibition⁹⁷ EGFR inhibition⁹⁸
Metabolism	Inhibition of HIF1α⁹⁹ Activation of AMPK¹⁰⁰
Nutriceuticals	Polyphenols¹⁰¹ Phyto-oestrogens¹⁰²
Sex hormones	Castration¹⁰³ Oestrogens¹⁰⁴