Table 3.

Long-term changes in BASFI

Input	Mean	Sources
Annual rate of mSASSS change for mSASSS ≥10	1.440	Corbett et al (2014)28
BASFI change associated with 1 unit change in mSASSS	0.057	Corbett et al (2014)28
Biologic treatment effect on progression for comparators	0.420	Corbett et al (2014)28
Biologic treatment effect on progression for secukinumaba	0.153	Calculated from MEASURE 1 trial data and using overall background progress rate from Ramiro et al (2015)50
Time to treatment effect (years)	0	Assumption

Notes: The long-term changes in BASFI were assessed by progression of radiographic disease measured by mSASSS score.

^aThis figure was calculated using the overall background progression rate of 0.98 units/year from the study by Ramiro et al (2015)⁵⁰ and the MEASURE 1 week 104 mSASSS progression figure of 0.3.

Abbreviations: BASFI, Bath Ankylosing Spondylitis Functional Index; mSASSS, modified Stoke Ankylosing Spondylitis Spine Score.