Table 2. Type of carbapenemase enzyme detected in carbapenemase-producing Enterobacteriaceae isolates from bloodstream infections reported to the national surveillance system, Italy, 2014–2017.
| Carbapenemase enzyme | Klebsiella pneumoniae | Escherichia coli | Total | |||
|---|---|---|---|---|---|---|
| N | % | N | % | N | % | |
| KPC | 4,323 | 95.2 | 57 | 81.4 | 4,380 | 95.0 |
| MBLa | 87 | 1.9 | 12 | 17.1 | 99 | 2.1 |
| KPC + MBLb | 43 | 0.9 | 0 | 0.0 | 43 | 0.9 |
| OXA-48 | 55 | 1.2 | 1 | 1.4 | 56 | 1.2 |
| MBLc + OXA-48 | 15 | 0.3 | 0 | 0.0 | 15 | 0.3 |
| KPC + OXA-48 | 3 | 0.1 | 0 | 0.0 | 3 | 0.1 |
| NDd | 16 | 0.4 | 0 | 0.0 | 16 | 0.3 |
| Not indicated | 2,948 | – | 72 | – | 3,020 | – |
| Total | 7,490 | – | 142 | – | 7,632 | – |
KPC: Klebsiella pneumoniae carbapenemase; MBL: metallo-beta-lactamase; ND: not determined; NDM: New Delhi metallo-beta-lactamase; OXA-48: carbapenem-hydrolysing oxacillinase-48; VIM: Verona integron-encoded metallo-beta-lactamase.
a Genotyping available for 59 MBLs: 51 VIM (47 in K. pneumoniae; 4 in E. coli) and 8 NDM (7 in K. pneumoniae; 1 in E. coli).
b Genotyping available for 13 MBLs: 11 VIM and 2 NDM (all in K. pneumoniae).
c Genotyping available for 14 MBLs: 3 VIM and 11 NDM (all in K. pneumoniae).
d Not determined (discrepancy between genotypic and phenotypic results).
Percentages were calculated excluding those isolates without enzyme identification.