Fig. 3.

Role of autophagy in skeletal muscle performance. Autophagy might carry out basic functions such as component recycling and energy support in skeletal muscle. Aging inhibits autophagy formation in skeletal muscle through multiple factors such as accumulation of misfolded proteins or dysfunctional mitochondria. In order to repair muscle damage, the exercise is required to induce autophagy, which results satellite cell activation, muscle mass maintenance, fiber type switching, and muscle adaptation. Autophagy formation might be beneficial event for the muscle performance through regeneration and remodeling in skeletal muscle.