Table 3. Baseline characteristics of the high mononuclear cell mtDNA copy number group and the low group in sepsis patients.
| Variable | High mtDNA copy number (≥362.61, n = 100) |
Low mtDNA copy number (<362.61, n = 100) |
P value |
|---|---|---|---|
| Age (y) | 60.55±15.74 | 60.02±16.38 | 0.816 |
| Male (n, %) | 75 (75.00) | 74 (74.00) | 0.871 |
| Underlying diseases | |||
| Diabetes mellitus (n, %) | 14 (14.00) | 20 (20.00) | 0.259 |
| Hypertension (n, %) | 40 (40.00) | 33 (33.00) | 0.304 |
| Cardiac disease (n, %) | 18 (18.00) | 15 (15.00) | 0.568 |
| Nephropathy (n, %) | 2 (2.00) | 6 (6.00) | 0.149 |
| Initial suspected infection site (n, %) | 0.546 | ||
| Lung | 68 (68.00) | 75 (75.00) | |
| Abdomen | 17 (17.00) | 13 (13.00) | |
| Other | 15 (15.00) | 12 (12.00) | |
| ICU length of stay (days) | 6.00 (4.00–13.00) | 6.00 (3.00–15.75) | 0.649 |
| SOFA score | 6.44±2.82 | 6.79±3.16 | 0.410 |
| In-hospital mortality (n, %) | 24 (24.00) | 38 (38.00) | 0.032 |
| Laboratory data† | |||
| WBC (×109 /L) | 13.79±7.15 | 13.14±7.40 | 0.527 |
| Platelet (×109 /L) | 174.09±94.28 | 194.33±111.42 | 0.167 |
| Hemoglobin (g/L) | 109.03±29.03 | 108.86±26.24 | 0.965 |
| Lactate (mmol/L) | 2.43±2.24 | 2.59±2.32 | 0.625 |
| AST (IU/L) | 35.00 (22.00–72.00) | 38.00 (23.00–104.00) | 0.137 |
| ALT (IU/L) | 26.00 (12.00–68.00) | 30.00 (14.00–79.00) | 0.952 |
| SCr (umol/L) | 121.27±108.23 | 95.34±73.79 | 0.049 |
| BUN (mmol/L) | 10.85±8.67 | 10.33±7.10 | 0.644 |
| CRP (mg/L) | 73.39±68.70 | 72.41±67.88 | 0.919 |
Note: ICU, intensive care medicine; SOFA, sequential organ failure assessment; WBC, white blood cell; AST, aspartate transaminase; ALT, alanine aminotransferase; SCr, serum creatinine; BUN, blood urea nitrogen; CRP, C-reactive protein
†, laboratory data at presentation in the patients group.