Table 5. Cox multivariate analyses: Factors associated with new onset AVN.
| Univariate HR (CI 95%) |
p | Multivariate AHR (CI 95%) |
p | |
|---|---|---|---|---|
| Gender (male) | 2.32 (0.76–7.04) | 0.14 | 2.07 (0.57–7.48) | 0.24 |
| Pre-transplant diabetes | 2.76 (1.08–7.01) | 0.033 | 2.27 (0.85–6.08) | 0.10 |
| BMI at transplantation ≥ 26 kg/m2 | 4.77 (1.70–13.4) | 0.0030 | 3.30 (1.00–10.86) | 0.049 |
| PTH at transplantation > 300 ng/L | 2.68 (1.02–7.05) | 0.046 | 2.10 (0.79–5.60) | 0.13 |
| Cumulative corticosteroid dose at M3 | 2.11 (1.52–2.93) * | < 0.0001 | 1.55 (1.03–2.32) * | 0.034 |
| Acute rejection at M24 and before AVN | 2.48 (0.93–6.64) | 0.070 | 1.69 (0.55–5.17) | 0.35 |
Model included factors associated with NOAVN in univariate analysis with p < 0.2
AHR: adjusted hazard ratio; AVN: avascular osteonecrosis; BMI: body mass index: M3 and M24: 3 and 24 post-transplant months
* by 500 mg of corticosteroid