Table 2. Mortality rates and mean time to death (MTD) of the LAV candidates in outbred CD-1 mice after primary subcutaneous or intracerebral infection.

Virus	Subcutaneous (sc) Infection			Intracerebral (ic) Infection
	# surviving mice	Survival (%)	MTDa ± STDb (days)	# surviving mice	Survival (%)	MTD ± STD (days)
WT EEEV FL93-939	2/24c	8.3	5.0 ± 1.1	0/8d	0	2.4 ± 0.4
5’U4&6	11/24	45.8	8.2 ± 1.3	1/6	16.7	4.2 ± 1.8
C65-69	22/24	91.7	7.5 ± 0.7	2/6	33.3	5.1 ± 0.3
E71-77	1/24	4.2	5.5 ± 0.5	0/8	0	4.3 ± 0.8
3’U11337	21/23	91.3	6.3 ± 0.4	0/8	0	2.9 ± 0.8
5’U4&6 C65-69	24/24	100	N/A	6/6	100	N/A
5’U4&6 E71-77	24/24	100	N/A	5/6	83.3	5 ± 0.0
5’U4&6 3’U11337	24/24	100	N/A	2/6	33.3	5.8 ± 0.9
C65-69 E71-77	19/24	79.2	6.9 ± 0.6	3/6	50	6 ± 0.7
C65-69 3’U11337	23//23	100	N/A	0/6	0	4.9 ± 1.0
E71-77 3’U11337	15/23	65.2	6.4 ± 1.5	0/8	0	3.9 ± 0.5
5’U4&6 C65-69 E71-77	29/29	100	N/A	6/6	100	N/A
5’U4&6 C65-69 3’U11337	30/30	100	N/A	6/6	100	N/A
5’U4&6 E71-77 3’U11337	32/32	100	N/A	6/6	100	N/A
5’U4&6 C65-69 E71-77 3’U11337	33/33	100	N/A	6/6	100	N/A

^aMTD: Mean time to death of mice succumbing to infection

^bSTD: Standard deviation

^cSubcutaneous infection: 6–8 independent experiments.

^dIntracerebral infection: 2–3 independent experiments