Figure 3: Probability of Treatment Disruption by Paclitaxel Exposure.
The probability of experiencing PN-Induced Treatment Disruption Increases as exposure (Tc>0.05 or Cmax) during the first dose increases. Assuming a patient has a baseline CIPN8=0 and receives the full dose (80 mg/m2) for 12 scheduled weekly doses, she would have a 25% risk of treatment disruption if her Tc>0.05=14.06 hours (Figure 3A) or Cmax=2,885 ng/mL (Figure 3B)).