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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Clin Cancer Res. 2018 Apr 27;24(15):3602–3610. doi: 10.1158/1078-0432.CCR-18-0656

Figure 3: Probability of Treatment Disruption by Paclitaxel Exposure.

Figure 3:

The probability of experiencing PN-Induced Treatment Disruption Increases as exposure (Tc>0.05 or Cmax) during the first dose increases. Assuming a patient has a baseline CIPN8=0 and receives the full dose (80 mg/m2) for 12 scheduled weekly doses, she would have a 25% risk of treatment disruption if her Tc>0.05=14.06 hours (Figure 3A) or Cmax=2,885 ng/mL (Figure 3B)).