Table 2:

Models of Increase in Self-Reported Sensory Peripheral Neuropathy

	Base Model and Univariate Associations of Clinical Variables			Multivariable Model Including Significant Clinical Variables
	B Coefficient	Standard Error	p-value	B Coefficient	Standard Error	p-value
Baseline CIPN8	0.20	0.03	<0.0001	0.21	0.04	<0.0001
Cumulative Dose	0.42	0.05	<0.0001	0.41	0.05	<0.0001
Relative Dose Intensity	−1.84	0.74	0.013	−1.37	0.74	0.07
Tc>0.05	−0.11	0.10	0.27	0.01	0.10	0.93
Cmax*	−0.002	0.10	0.99	NA	NA	NA
Age	−0.02	0.01	0.015	−0.02	0.01	0.020
Nonwhite vs. White Race	0.43	0.41	0.30	NA	NA	NA
Alcohol vs. None	0.84	0.19	<0.0001	0.60	0.20	0.003
Diabetes vs. No Diabetes	0.41	0.23	0.08	0.42	0.25	0.09

^*Notes: The above estimates and p-values are for the base model with baseline CIPN8, cumulative dose, relative dose intensity and T_c>0.05. Both T_c>0.05 and C_max are in standard deviation units. The clinical variables (age, race, alcohol, and diabetes) were first tested individually for their contribution to the base model, and if p<0.10 were included in the multivariable model. The outcome of the model is the square root of the CIPN8 score. These models included an intercept estimate with no meaningful interpretation, thus the intercept data are not shown. Significant p-values (<0.05) are bolded