Table 3:

Base Model of Risk of Peripheral Neuropathy-Induced Treatment Disruption

	Odds Ratio	95% Confidence Interval	p-value
Baseline CIPN8	0.95	0.76–1.19	0.64
Cumulative Dose	1.46	1.18–1.80	0.0008
Tc>0.05	1.79	1.06–3.01	0.029
Cmax*	2.74	1.45–5.20	0.002
Age	0.98	0.91–1.05	0.50
Alcohol vs. No Alcohol	1.60	0.42–6.17	0.49
Diabetes vs. No Diabetes	1.94	0.41–9.13	0.40

^*Notes: The above estimates and p-values are for the base model with baseline CIPN8, cumulative dose, and T_c>0.05. The model with C_max only was not meaningfully different (Baseline CIPN 8 OR=0.93, 95% CI: 0.75–1.17, p=0.54, Cumulative dose OR=1.49, 95% CI: 1.19–1.87, p=0.0009). The odds ratios were calculated as one unit offsets from the mean with other variables set at the mean. Both T_c>0.05 and C_max are in standard deviation units. Model with race does not converge due to low variability in race and having events. Since none of the clinical variables were associated with neuropathy, a multivariable model including clinical variables was not created. These models included an intercept estimate with no meaningful interpretation, thus the intercept data are not shown. Significant p-values (<0.05) are bolded.