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. Author manuscript; available in PMC: 2020 Feb 12.
Published in final edited form as: Biochemistry. 2018 Dec 18;58(6):438–449. doi: 10.1021/acs.biochem.8b01004

Figure 5: Internal protein motions and conformational fluctuations allow sampling of conformational sub-states.

Figure 5:

Protein motions at fast time-scales allow sampling within a sub-state, while fluctuations at long time-scales allow access to different sub-states. Some of these higher energy states may contain function promoting structure and dynamical features. Any factors that change the sampling of the higher energy conformational will change access to these functionally important states and therefore change the rate of the reaction.