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. 2019 Feb 8;8:e42386. doi: 10.7554/eLife.42386

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© 2019, Salazar et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 12. — (a) Cartoon summarizing regulatory analysis of Sp7 locus by chromatin immunoprecipitation of H3-acetyl-K14, Smad1, endogenous Grhl3, or transiently expressed V5-GRHL3 from chromatin of immortalized E13.5 limb bud cell cultures grown in presence of recombinant BMP2 or Noggin. (b) QPCR analysis revealed BMP-dependent enrichment of these proteins at a putative consensus-binding motif for Grhl3 located at a (c) highly conserved genomic region ˜13 kb upstream of the Sp7 transcription start site. Data reflect mean ±distribution in two independent experiments.