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. 2019 Feb 8;8:e42386. doi: 10.7554/eLife.42386

Figure 13. Developmental, reparative, and therapeutic signals converge on Bmp2 to specify osteoblasts in the periosteal niche.

Figure 13.

(a) A proposed hierarchical and regionalized gene regulatory network, summarizing the source and identity of signals that regulate transcription of Bmp2 for downstream specification of Sp7+/Col1A1+ osteoblasts in the periosteal niche. Boxed regions, biological compartments; Boxed text, inputs evaluated in this study; Double arrows in a link, communication across territories; Flat footpads ending at genetic loci, transcriptional inhibition; Pointed footpads ending at genetic loci, transcriptional induction; Diamonds under footpads, evidence of direct cis-regulatory interaction provided by our study; White bubbles, protein/protein interactions. Made with Biotapestry.org.