Figure 4. Bmp2 is dispensable for development and maintenance of the periosteum.

(a,b) The periosteum forms during development and is maintained in postnatal life in Bmp2 Prx1-cKO mice. Sagittal sections of the femur from mice were stained with picrosirius red and hematoxylin, and imaged by brightfield (left panels) or polarized light (right panels) microscopy. Images shown are representative of femurs harvested from littermates at ages (a) embryonic day 17.5, (b) postnatal day 0, or (c) postnatal day 14. Arrowheads point to the outer collagen-rich canopy of periosteum in Bmp2 Prx1-cKO mice.