Figure 7. Bmp2 acts downstream of intermittent parathyroid hormone treatment in the adult periosteum.
Intermittent PTH1-34 therapy does not improve biomechanical stability or fracture repair in adult Bmp2 Prx1-cKO mice. (a) Adult mice were given intermittent PTH1-34 therapy (100 mg/kg, subcutaneous) for (b–g) 14 days or (h) 21 days. (b–d) Quantitative microCT and biomechanical analysis on adult mice treated 2 weeks with PTH1-34 (n = 3–5), presented as mean ±s.d. where *p<0.05 vs. matched genotype vehicle control. (b) Ratio of bone volume (BV) to trabecular volume (TV). (c) Peak moment as a function of IMIN/CMIN. (d) Predicted minimum moment of inertia. (e–h) Incidence of femoral or forelimb fractures in adult mice treated (e–g) two weeks (n = 4–5 per group) or (h) 21 days (n = 8 per group) with PTH1-34. Biomechanics are reported as mean ±s.d, where P-value was calculated using 1-way ANOVA and post-test Newman Keulus. All data points were included in the analysis. Remaining group comparisons were made by 2-way ANOVA and Tukey’s multiple comparison tests.