Table 2. Skeletal phenotype of 2 week-old Bmp2Flox/Flox; Prx1-Cre mice.
Quantitative microCT data presented as mean ±s.d. where ***p<0.0005 vs. age-matched Bmp2F/F littermates when compared by 1-way ANOVA. (e) Static histomorphometry (n = 4), presented as mean ±s.d. *p<0.05 vs. age-matched Bmp2F/F littermates. Abbreviations: BV/TV, trabecular bone volume to total tissue volume; Tb.Th, trabecular thickness; Tb.Sp. trabecular spacing; Tb.N. trabecular number; Tt.Ar, total cross-sectional tissue area at the mid-diaphysis; Ct.Ar, cortical bone area; Ct.Ar/Tt.Ar, cortical bone area as a fraction of total tissue area; C.Th cortical thickness; Ma.Ar, marrow area; IMIN, minimum moment of inertia; TMD, tissue mineral density.
| MicroCT femur, P14 | Bmp2Flox/Flox | Bmp2Flox/Flox; Prx1-Cre |
|---|---|---|
| N | 4 | 4 |
| BV/TV (%) | 4.3 ± 1.0 | 6.6 ± 0.9 |
| Tb.Th (mm) | 0.02 ± 0.001 | 0.02 ± 0.001 |
| Tb.Sp. (mm) | 0.35 ± 0.04 | 0.26 ± 0.06 |
| Tb.N (1/mm) | 2.8 ± 0.3 | 3.9 ± 1.0 |
| Tt.Ar (mm2) | 1.02 ± 0.08 | 0.6 ± 0.03*** |
| Ct.Ar (mm2) | 0.24 ± 0.03 | 0.21 ± 0.01 |
| Ct.Ar/Tt.Ar (%) | 23 ± 0.2 | 36 ± 1.0*** |
| C.Th (mm) | 0.065 ± 0.07 | 0.06 ± 0.03 |
| Ma.Ar (mm2) | 0.46 ± 0.04 | 0.23 ± 0.02*** |
| Imin (mm4) | 0.02 ± 0.005 | 0.01 ± 0.001*** |
| TMD (mgHA/cm3) | 882.6 ± 20.6 | 858.7 ± 8.57 |