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At least half of the subjects in each group recognize heterologous antigens. (A) One month after exposure, ≥50% of the subjects showed reactivity to heterologous CSP and MSP. (B) Almost all the heterologous anti-CSP responses after PvCHMI and PfCHMI were IgM. (C) After PfCHMI, similar numbers of subjects had IgM and IgG antibodies directed against PvMSP, while after PvCHMI, higher anti-PvMSP IgM responses were observed.
