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. 2019 Feb 21;87(3):e00846-18. doi: 10.1128/IAI.00846-18

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Copyright © 2019 Chan et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 2 — MAV is immunogenic in a mouse model of subcutaneous vaccination. CD1 mice were vaccinated subcutaneously with 75 μg on day 0 and day 21 and culled at 28 days to obtain serum. (A) Results of a whole-cell IgG ELISA against S. pneumoniae TIGR4 for pooled sera harvested from tail vein bleeds (10 μl per mouse, n = 6). (B and C) Results of whole-cell IgG and IgM ELISAs against S. pneumoniae TIGR4 for pooled sera from MAV-vaccinated mice (n = 5) (B) and against S. pneumoniae TIGR4 for pooled BALF and nasal wash specimens from MAV-vaccinated mice (C). Data are presented as the mean and 95% confidence interval. P values were calculated using the Mann-Whitney t test. **, P < 0.01; ns, not significant.