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IC50 values for the displacement of 1a-TOQ and for the inhibition of r(G4C2)66-mediated RAN translation.
| Compound | Displacement of 1a-TOQ IC50 (μM) |
Inhibition of RAN Translation IC50 (μM) |
|---|---|---|
| 1a | 2.6 ± 1.0 | 11 ± 1.0 |
| 1 | 1.3 ± 0.5 | 0.27 ± 0.05 |
| 2 | 1.4 ± 0.4 | >25 |
| 3 | 0.9 ± 0.2 | 12 ± 2.0 |
| 4 | 8.5 ± 2.0 | 1.6 ± 0.20 |
| mo(G2C4)4 | - | 7.6 ± 1.0 |
