Fig. 5.

Role of accumulated mutation burden in driving diminished lifespan and increased doubling time in diploid yeast. (A) Scatterplot showing the relationship between mutation burden [SNVs per megabase (Mb)] and median RLS in diploid mutator yeast (black; Fig. 2), passaged pol3-01/pol3-01 msh6Δ/msh6Δ strong mutators (purple; Fig. 3), and transiently mutagenized MA lines (gold; Fig. 4). Error bars, 95% confidence intervals. (B) Correlation between log-transformed mutation burden and peak doubling time.