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Relative orientation of domains in MACPF proteins. (A) Superposition of MACPF domains from GNIP1Aa (yellow) and PlyB (red) results in different positioning of the C-terminal domains in GNIP1Aa (cyan) and PlyB (green). (B) Domain orientation in perforin (yellow) with C2 domain in cyan. (C) Domain orientation in Plu-MACPF (yellow) with β-prism domain in cyan.
