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All three HuR RRM domains are involved in ARE binding. (A) Schematic representation of HuR domain organization, with the RRM12 and RRM3 construct lengths indicated. The RRM3 amino acid sequence including the secondary structure is highlighted. (B) Schematic representation of the c-fos mRNA with the ARE 11-mer used in this study. (C and D) ITC binding curves of RRM12 (C) or RRM3 (D) with the c-fos ARE 11-mer. Errors indicate SD of two (RRM12) or three (RRM3) measurements.
