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RNA-poise model. In this model, the transcripts of one gene (RNA 1, red bar) can exhibit spatial proximity to another gene (RNA 2, purple bar) due to tethering (RNA targeting) or spatial proximity of the two genes (RNA confinement). Both cases could enhance splicing errors (gray arrows), whereas the proximity of genomic sequences may also facilitate gene fusion (gray arrow on the right), which subsequently produces fusion RNA.
