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. 2019 Feb 22;8(3):15. doi: 10.1038/s41389-019-0121-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, b CTSB knockdown in two independent clones (shCTSB1 and shCTSB2 vs vector control LKO) reduced RNA levels of CTSB as assayed by real-time PCR. c, d Reduced levels of full-length and cleaved (active) CTSB protein, as assayed by immunoblot. e–h CTSB reduction (shCTSB1 and shCTSBs2) in both the 786-O and A498 lines reduced colony formation as compared to LKO. i–j CTSB down-modulation in 786-O or in A498 cells reduced cell proliferation, as assessed by luminometry