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. 2019 Feb 22;39(2):BSR20182058. doi: 10.1042/BSR20182058

Figure 4. Comparison of representative pathological findings between initial biopsy and repeated biopsy.

Figure 4

BKV cytopathic changes and SV40 large T antigen staining before (A,B) and after (C,D) treatment. Initial biopsy show nuclear enlargement and nuclear inclusions within tubular epithelial cells (A). The SV40 large T antigen staining (B) shows extensive staining in the nuclei in the infected tubules. After switching to low-dose cyclosporine, the viral cytopathic changes become sparse or unrecognizable on Hematoxylin and Eosin staining. SV40 large T antigen staining (D) shows infected nuclei in isolated cells.