Figure 2.

Advanced materials and devices for the study and regulation of NK cells: (a) Lipid bilayer with incorporated ligands that mimic the surface of target cells. (b) Ligands tethered to a pattern of nanodots that determine arrangement individual receptors onto a fixed 2D architecture. (c) Surface with ligand micropatterns that determine receptor clustering. (d) Devices for physical guidance and confinement of NK cells, alone as well as in a pair with target cells. (e) Nanomaterials for controlled ligand delivery on 3D (f) devices for mechanical stimulation of NK cells. Activating or inhibitory ligand-receptor pairs are schematized as in Figure 1.