Figure 3.

(a) Schematic illustration of an artificial immune synapse between NK cell and supported lipid bilayer. Reproduced with permission from Reference [32]. The bilayer includes incorporated ligands recognized by NK cell receptor. The planar interface between the cell membrane and the bilayer enables facile microscopic imaging of the synapse. (b) STED imaging of NK synapse on supported lipid bilayer. NK cells were activated on lipid bilayer with incorporated anti-CD16 (red), fixed, permeabilized, and stained with perforin (blue), and anti-(F-actin) (green). Scale bar: 1 µm. Reprinted with permission from Reference [31].