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. 2019 Feb 6;20(3):707. doi: 10.3390/ijms20030707

Table 1.

Cytokines and other compounds stimulating podoplanin expression.

Cytokine/Compound Cell Type Reference
LTβR ligands Reticular cell (FRC, FDC) [78]
TNF-α Macrophage
Monocyte
Synovial fibroblast
Dermal fibroblast		 [85]
[111]
[139,141]
[149]
TGF-β1 Keratinocyte
Synovial fibroblast
SCC
Fibrosarcoma		 [89]
[139]
[214]
[215]
IFN-α Keratinocyte [89]
VEGF-C Monocyte [111]
IL-1β Synovial fibroblast
Dermal fibroblast		 [139,141]
[149]
IL-3 LEC
BEC 1
Monocyte		 [109]
[110]
[111]
IL-6 Keratinocyte [89]
IL-7 EC 2 [108]
IL-22 Keratinocyte [89]
LPS Macrophage
Monocyte		 [85]
[111]
Fibronectin Monocyte [111]
TPA Keratinocyte
Dermal fibroblast		 [88,93]
[88]

1 At a low level; 2 Endothelial cells with mixed vascular and lymphatic characteristics. LPS: lipopolysaccharide; TPA: 12-O-tetradecanoylphorbol 13-acetate; FRC: fibroblast-like reticular cells; FDC: follicular dendritic cell; SCC: squamous cell carcinoma; LEC: lymphatic endothelial cell; BEC: blood endothelial cell.